Naltrexone HCl Oral Liquid compounded for dogs and cats.

Overview

Naltrexone HCl is an active pharmaceutical ingredient (API) that may be prescribed by veterinarians to help manage certain chronic conditions in dogs and cats. Although not FDA-approved for veterinary use, Naltrexone can be compounded into an oral liquid formulation when no suitable alternatives are available. This preparation allows for customized dosing and easy administration, especially for small pets or those with unique medical needs.

Key Benefits of Naltrexone Oral Liquid

• Custom-Dosed for Pets: Each prescription is compounded based on the specific instructions from your veterinarian, ensuring accurate, individualized dosing.


• Flavored Liquid for Easy Dosing: The oral liquid format makes it easier for pet owners to administer and adjust doses as prescribed.


• Supports Broader Treatment Plans: Naltrexone may be included in a comprehensive treatment protocol for pets managing chronic inflammation, immune dysfunction, or discomfort.


• High-Quality Ingredients: All APIs used in our compounded formulations, including Naltrexone HCl, are sourced from FDA-registered facilities to ensure quality and safety.


• Rapid Processing: We prioritize timely turnaround and shipping so pets can begin their treatment without delay.

Mechanism of Action & Use in Animals

At low doses, Naltrexone briefly blocks opioid receptors in the body, prompting a compensatory release of natural endorphins and enkephalins. This "rebound" effect may support immune modulation and improve pain tolerance. While more studies are needed, veterinarians may prescribe compounded Naltrexone to support pets with:

 

• Chronic pain or inflammation


• Autoimmune-related conditions


• Anxiety or affective disorders


• Cancer-related inflammation


• Neurological dysfunction

 

Its immune-modulating properties and favorable safety profile at low doses make it an option worth considering in carefully managed treatment plans.

Safety & Administration Guidance

• Dosing: Low-dose Naltrexone (LDN) is typically administered in doses ranging from 0.5mg to 4.5mg depending on the species, condition, and weight. Your veterinarian will determine the most appropriate starting dose and any gradual increases.


• Missed Doses: If you miss a dose, administer it as soon as possible. Skip the missed dose if it's near the next scheduled time—do not double up.


• Storage: Store oral liquid in its original container at room temperature and shake well before use.


• Possible Side Effects: Most pets tolerate LDN well. However, some may experience mild restlessness, agitation, or a temporary flare in symptoms during the initial weeks.


• Precautions: Do not use in conjunction with opioid medications. Use only under veterinary supervision.

Additional Dosage Forms Available

Naltrexone Capsules for Dogs and Cats

For pets who tolerate solid formulations, Naltrexone is also available in capsule form. Learn more here.

Regulatory Compliance

• Patient-Specific Compounding: Naltrexone oral liquid is compounded specifically for your pet based on a valid prescription. This product is not FDA-approved for veterinary use and is prepared in accordance with FDA GFI #256 when no suitable alternatives are available.


• Best Practices: Our pharmacy follows the guidelines of the Alliance for Pharmacy Compounding, maintaining high standards for safety, transparency, and ethical marketing.

Have Questions About Low-Dose Naltrexone?

If you’d like to discuss how Low-Dose Naltrexone might fit into your patient’s care plan, we’d love to connect.

Click here to schedule a time with one of our pharmacists.

We’re happy to answer questions, provide dosing guidance based on your prescription, and help ensure your patients receive customized, high-quality care.

Important Notes

• Prescription Required: Naltrexone oral liquid requires a valid prescription from a licensed veterinarian. Always consult your veterinarian to determine if this medication is appropriate for your pet.


• Use in a Broader Plan: Naltrexone is typically used alongside other therapies and is not intended as a standalone solution.

Prescribe Naltrexone Oral Liquid for Dogs and Cats Today

Support your patients with a flexible, immune-modulating treatment option. Prescribe Naltrexone oral liquid to help address chronic inflammatory or immune-related conditions in dogs and cats—compounded with care, precision, and quality ingredients.