Bethanechol for Cats and Dogs

Same active ingredient as Urecholine®

Class of Agent -Cholinergic

Uses – Bethanechol is used primarily to stimulate bladder contractions in small animals. in animals with detrusor hyporeflexia or bladder atony, bethanechol chloride may be of some benefit. This cholinergic agonist stimulates the initiation of the detrusor muscle contraction.

Mild adverse effects are usually:

• Vomiting
• Diarrhea
• Salivation
• Anorexia (more likely to occur)

Popular Strengths and Dosage Forms:

• Bethanechol 5mg/mL Flavored Oral Liquid
• Bethanechol 10mg/mL Flavored Oral Liquid
• Bethanechol 2.5mg Flavored Chewable
• Bethanechol 5mg Flavored Chewable
• Bethanechol 5mg Tablets
• Bethanechol 10mg Tablets

Contact one of our pharmacists for custom strengths and dosages.

WARNINGS:

• Give medication on an empty stomach unless otherwise directed by your veterinarian.
• See your veterinarian if our pets shows signs of salivation, vomiting, diarrhea or anorexia.

References – Plumb’s Veterinary Drug Handbook, 7th Edition, Donald C. Plumb, 2011

The Merck Veterinary Manual, Tenth Edition, 2010

Diethylstilbestrol (DES) for Dogs

Class of Agent -Hormonal Agent

Uses – Diethylstilbestrol (DES) is a nonsterodial estrogen derivative that is frequently used in estogen responsive urinary incontinence. It is an attractive option for treating urinary incontinence due to its infrequent administration and affordability. DES is currently the most commonly used drug for acquired urinary incontinence in spayed female dogs and has been reported to lead to continence in 60% to 80% of treated dogs.

Side effects may include:

• Reversible alopecia
• Signs of estrus
• Behavioral changes
• Bone Marrow suppression

Popular Strengths and Dosage Forms:

• Diethylstilbestrol 1mg Mini-Tablet
• Diethylstilbestrol 0.5mg Capsule
• Diethylstilbestrol 5mg Capsule
• Diethylstilbestrol 1mg Flavored Chewable
• Diethylstilbestrol 0.5mg Flavored Chewable

Contact one of our pharmacists for custom strengths and dosages.

WARNINGS:

• Be on the lookout for signs of lethargy, diarrhea, vomiting, abnormal discharge from vulva, excessive water consumption and urination or abnormal bleeding.
• Do not use in dogs with known hypersensitibity to the drug or in pregnant dogs.
• DES should be avoided in nursing dogs.

References – Plumb’s Veterinary Drug Handbook, 7th Edition, Donald C. Plumb, 2011

International Journal of Pharmaceutical Compounding Volume 16 No.5,

Imipramine HCl for Dogs and Cats

Class of Agent -Tricyclic Antidepressant

Uses – Imipramine has been used to treat cataplexy and urinary incontinence in dogs and cats. It has also been used to treat narcolepsy and ejaculatory dysfunction in horses.

Most commonly reported side effects:

• Sedation
• Anticholinergic effects (tachycardia, hyperexcitability, tremors)
• May reduce seizure thresholds in epileptic animals

Popular Strengths and Dosage Forms:

• Imipramine HCl 10mg/mL Flavored Oral Liquid
• Imipramine HCl 5mg Flavored Chewable
• Imipramine HCl 10mg Flavored Chewable

Contact one of our pharmacists for custom strengths and dosages.

WARNINGS:

• Keed away from children and other pets.
• Several weeks may be required before efficacy is noted therefere continue dosing as directed.

References – Plumb’s Veterinary Drug Handbook, 7th Edition, Donald C. Plumb, 2011

Phenoxybenzamine for Dogs, Cats and Horses

Class of Agent -Alpha-Adrenergic Blocker

Uses – Phenoxybenzamine is used to treat urinary retention largely for it positive results in decreasing internal urethral sphincter tone in dogs and cats when urethral sphincter hypertonus is present. Phenoxybenzamine has also been used to treat laminitis in its early stages as well as secretory diarrheas.

Most commonly reported side effects:

• Hypotension
• Hypertension
• Miosis
• Increased intraocular pressure
• Tachycardia
• Sodium Retention
• Inhibition of ejaculation
• Nasal congestion

Popular Strengths and Dosage Forms:

• Phenoxybenzamine 2.5mg Capsule
• Phenoxybenzamine 5mg Capsule
• Phenoxybenzamine 10mg/mL Flavored Oral Liquid
• Phenoxybenzamine 5mg/mL Flavored Oral Liquid
• Phenoxybenzamine 5mg Flavored Chewable
• Phenoxybenzamine 10mg/0.1mL Transdermal Gel

Contact one of our pharmacists for custom strengths and dosages.

WARNINGS:

• Contact your veterinarian if your pet appears weak, dizzy, collapses after standing, or has persistent vomiting.
• Given with food may reduced GI upset.

References – Plumb’s Veterinary Drug Handbook, 7th Edition, Donald C. Plumb, 2011

Merck Veterinary Manual, Tenth Edition, 2012

Phenylpropanolamine (PPA) for Dogs

Class of Agent -Sympathomimetic

Uses – Phenylpropanolamine (PPA) is used to treat acquired urinary incontinence in dogs. Reports show that seventy-five precent of incontinent female dogs treated with sympathomimetics become continent and dogs treated with PPA specifically show a 90% response rate. PPA has also been used to treat nasal congestion in small animals.

PPA is generally well tolerated in dogs.

Most commonly reported side effects:

• Vomiting
• Hypertension
• Anorexia
• Weight loss
• Restlessness
• Panting
• Proteinuria
• Behavioral changes

Popular Strengths and Dosage Forms:

• Phenylpropanolamine 12.5mg/0.1mL Transdermal Gel
• Phenylpropanolamine 50mg/mL Flavored Oral Liquid
• Phenylpropanolamine 12.5mg Capsules
• Phenylpropanolamine 10mg Flavored Chewables
• Phenylpropanolamine 50mg Flavored Chewables
• Phenylpropanolamine 100mg Flavored Chewables

Contact one of our pharmacists for custom strengths and dosages.

WARNINGS:

• Use with caution in dogs with pre-existing heart disease, kidney insufficiency and hypertension.
• Provide plenty of water as PPA may cause increased thirst.

References – Plumb’s Veterinary Drug Handbook, 7th Edition, Donald C. Plumb, 2011

International Journal of Pharmaceutical Compounding Volume 16 No.5,